Stroke. 2000;31:2287. Serum Vitamin C Concentration Was Inversely Associated With Subsequent 20-Year Incidence of Stroke in a Japanese Rural Community The Shibata Study Full text
Plasma Vitamin C Modifies the Association Between Hypertension and Risk of Stroke. Stroke, 2002;33:1568-1573 S. Kurl, MD; T.P. Tuomainen, MD; J.A. Laukkanen, MD; K. Nyyssönen, PhD;
Hampl JS, Taylor CA, Johnston CS. "Vitamin C deficiency and depletion in the United States: the Third National Health and Nutrition Examination Survey, 1988 to 1994." Am J Public Health 2004; 94(5): 870-875
Cathcart RF. Vitamin C, Titrating To Bowel Tolerance, Anascorbemia, and Acute Induced Scurvy. Medical Hypotheses 1981; 7: 1,359-1,376
Vitamin C, the L and R isomers: Wikipedia
Thomas Levy MD on Vitamin C
Linus Pauling Institute References for Vitamin C
Knekt P, et al. "Antioxidant vitamins and coronary heart disease risk: a pooled analysis of 9 cohorts." Am J Clin Nutr 2004; 80(6): 1,508-1,520.
(9) http://www.seanet.com/~alexs/ascorbate/194x/klenner-fr-southern_med_surg-1949-v111-n7-p209.htm Klenner FR. “The Treatment of Poliomyelitis and Other Virus Diseases with Vitamin C.” Southern Medicine & Surgery 1949: 209
Ascorbic Acid and Some Other Modern Analogs of the Germ Theory. Journal of Orthomolecular Medicine, 1999; Vol 14 (3): 143-56. John T. A. Ely, Ph.D.Radiation Studies, Box 351310 University of WashingtonSeattle, WA 98195
Publications by Robert F. Cathcart MD
Is the Recommended Dietary Allowance for Vitamin C Too Low? by Bill Sardi
Dr. Hickey and Roberts Vitamin C recommendations
American Society for Nutrition J. Nutr. 137:2171-2184, October 2007
Critical Review New Developments and Novel Therapeutic Perspectives for Vitamin C
Yi Li and Herb E. Schellhorn. Vitamin C is an essential nutrient for the biosynthesis of collagen, L-carnitine, and the conversion of dopamine to norepinephrine (1). Under physiological conditions, it functions as a potent reducing agent that efficiently quenches potentially damaging free radicals produced by normal metabolic respiration of the body. Though most animals are able to synthesize large quantities of vitamin C endogenously, humans lost this capability as a result of a series of inactivating mutations of the gene encoding gulonolactone oxidase (GULO)3, a key enzyme in the vitamin C biosynthetic pathway. These mutational events were estimated to have occurred about 40 million years ago, rendering all descending species, including humans, ascorbic acid deficient. Acute lack of vitamin C leads to scurvy, manifest by blood vessel fragility, connective tissue damage, fatigue, and, ultimately, death.
J. Biol. Chem., Vol. 269, Issue 18, 13685-13688, 05, 1994
Cloning and chromosomal mapping of the human nonfunctional gene for L- gulono-gamma-lactone oxidase, the enzyme for L-ascorbic acid biosynthesis missing in man
M Nishikimi, R Fukuyama, S Minoshima, N Shimizu and K Yagi
Institute of Applied Biochemistry, Yagi Memorial Park, Gifu, Japan.
These findings indicate that the human nonfunctional L-gulono-gamma-lactone oxidase gene has accumulated a large number of mutations without selective pressure since it ceased to function during evolution.
Proc Natl Acad Sci U S A. 2001 August 14; 98(17): 9842–9846. A new recommended dietary allowance of vitamin C for healthy young women-90 mg. Mark Levine, Yaohui Wang, Sebastian J. Padayatty, and Jason Morrow
NIH Research Shows 100 to 200 Mg of Vitamin C Daily May Benefit Healthy Adults. Research from the National Institutes of Health (NIH) shows that healthy adults may benefit from daily intake of 100 to 200 milligrams of vitamin C, the Journal of the American Medical Association reports in its April 21 issue. The conclusion is based on recent findings about the mechanisms and action of vitamin C by Mark Levine, M.D. Levine says adults need about 200 mg of vitamin C daily,
Jeffrey Dach MD
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