Treatments to Rebuild Strong Bone and Collagen
In addition to cartilage, joints are made of bone material, so taking supplements to build strong bone makes sense. Bone is made of collagen, so supplements that are required for strong collagen formation are ones we want here.
1) Vitamin C is a key vitamin for strong collagen.
2) Silica (BioSil) is a new supplement that makes strong collagen.
3) Collagen is made from amino acids so, the amino acids-lysine, proline are useful.
4) Collagen strength comes from sulfer crosslinking, so the sulfer nutrient MSM is added.
Note: The above supplements are available to our patients at the office.
Glucosamine and Chondroitin for Arthritis Pain by Jeffrey Dach M.D.
Jeffrey Dach MD
7450 Griffin Rd Suite 180/190
Davie, FL 33314
References and Links:
"Menopausal Arthritis" May Develop in Women Receiving Estrogen-Depleting Treatments
News Author: Laurie Barclay, MD CME Author: Désirée Lie, MD, MSEd
Sept. 2, 2005 — Women receiving estrogen-depleting treatments may develop "menopausal arthritis," according to a review article published in the September issue of Arthritis & Rheumatism. The authors suggest that the symptoms are usually transient and resolve with estrogen therapy or when aromatase inhibitors are discontinued.
The authors review trial data showing that women treated with aromatase inhibitors often develop musculoskeletal and joint pain or aching sometimes leading to treatment discontinuation. They also review biologic mechanisms linking estrogen deprivation with joint pain, both in natural menopause and in pharmacologic estrogen deprivation.
Although estrogen is not known to specifically affect articular structures in a manner that would cause joint pain, it influences inflammation and neural processing of nociceptive input via tissue-specific effects on inflammatory cytokines and direct effects on opioid pain fibers in the central nervous system (CNS).
The best evidence that decreased estrogen production may cause arthralgias comes from trials of aromatase inhibitors for the treatment or prevention of breast cancer. Compared with women receiving placebo or tamoxifen, those receiving aromatase inhibitors have greater frequency of arthralgia.
When objective findings accompany arthralgias, this may result in an erroneous diagnosis of osteoarthritis or rheumatoid arthritis in women who might not otherwise be diagnosed.
Article: "Aromatase Inhibitors and the Syndrome of Arthralgias With Estrogen Deprivation,"
David T. Felson and Steven R. Cummings, Arthritis & Rheumatism, September 2005; 52:9; pp. 2594-2598.
Women treated with aromatase inhibitors often experience joint pain and musculoskeletal aching: severe enough, in some cases, to make them stop the treatment.
"Estrogen's effects on inflammation within the joint are not well known," Dr. Felson and Dr. Cummings observe. Yet, as they note, estrogen has well-established tissue-specific effects on inflammatory cytokines. Estrogen's role in joint inflammation could account for the increased sensitivity to pain that some women suffer with estrogen depletion. Citing studies of pharmacological suppression of estrogen and studies of natural menopause, the authors offer a look at compelling evidence associating estrogen deprivation with joint pain, including:
Anastrozole Associated With Joint Symptoms in Patients With Breast Cancer CME
News Author: Roxanne Nelson Author: Charles Vega, MD
Joint symptoms are most prominent in women in the fifth decade of life, and women who are postmenopausal are more likely to experience joint symptoms vs premenopausal or perimenopausal women of the same age. Hormonal therapy with estrogen can relieve these joint symptoms, whereas third-generation aromatase inhibitors promote joint symptoms.
The Lancet Oncology, Volume 9, Issue 9, Pages 866 - 872, September 2008
Risk factors for joint symptoms in patients enrolled in the ATAC trial: a retrospective, exploratory analysis
Ivana Sestak PhD a , Prof Jack Cuzick PhD a, Francisco Sapunar MD b, Prof Richard Eastell MD c, Prof John F Forbes FRACS d, Angelo R Bianco MD e, Aman U Buzdar MD f, on behalf of the ATAC Trialists' Group
Joint symptoms (eg, arthralgia and arthritis) are a well-known side-effect of aromatase inhibitors. Low oestrogen concentrations and postmenopausal status are associated with the development of these symptoms.
Breast. 2007 Jun;16(3):223-34. 2007 Mar 21
Aromatase inhibitor-associated arthralgia syndrome. Burstein HJ.
Aromatase inhibitors (AIs) are widely used as an adjuvant endocrine treatment in postmenopausal women with early-stage breast cancer. Clinical experience also suggests that AI therapy is associated with a novel musculoskeletal side effect consisting of an arthralgia syndrome. The actual incidence of AI-associated arthralgias or musculoskeletal symptoms is not known, though such symptoms are quite prevalent and appear more commonly with AI use than with tamoxifen. Arthralgias can be a reason for discontinuation of AI treatment.
NATURAL Treatment for Arthritis
Vegetable juicing diet-weight loss
Herbs- Boswellia, Ginger Curcumin
2) cartilage nutrients
glucosamine chondroitin MSM
3) bone nutrients-collagen fromation
AMino acids-lysine, proline
Sulfer crosslinking -MSM
Fish Oil for Arthritis
Collateral Benefits of Fish Oil Therapy for Rheumatoid Arthritis by CHAK SING LAU, MD, FRCP,Professor of Medicine, Division of Rheumatology & Clinical Immunology,
"Cod liver oil (n-3 fatty acids) as a non-steroidal anti-inflammatory drug sparing agent in rheumatoid arthritis," Galarraga B, Ho M, et al, Rheumatology, March 24 2008 [advance access published online]
James MJ, Cleland LG. Dietary n-3 fatty acids and therapy for rheumatoid arthritis. Semin Arthritis Rheum . 1997;27:85-97.
* Volker D, Fitzgerald P, Major G, et al. Efficacy of fish oil concentrate in the treatment of rheumatoid arthritis. J Rheumatol . 2000;27:2343-2346.
Are There Any Vitamins Or Herbal Supplements That Can Be Used To Treat Pain Resulting From Osteoarthritis? Tieraona Low Dog, M.D., Director of Education, Program in Integrative Medicine, University of Arizona January 2, 2008
Glucosamine, Devil's claw - south african herb used in Europe. Clinical trials done concluded effective. Standardized extract.
Bromalain- pineapple digestive enzymes.
Commonly used in Europe. Use enteric coated form to prevent break down from stomach acid. May have blood thinner effect.
Arthritis Foundation Statement on the Glucosamine/chondroitin Arthritis Intervention Trial
Summary ..The study did find that the combination of the two supplements provided significant pain relief for people with moderate-to-severe knee OA.
Even JAMA admits glucosamine is effective against osteoarthritic pain.
McAlindon TE and others. Glucosamine and chondroitin for treatment of osteoarthritis: A systematic quality assessment and meta-analysis JAMA 283:1469-1475, 2000.
Reginster JY and others. Long-term effects of glucosamine sulfate on osteoarthritis progression: a randomized, placebo-controlled trial. Lancet 357:251-256, 2001.
Experimental Biology 2000 Conference San Diego April 18, 2000
Niacin and Osteoarthritis
Reprinted with permission from Saul AW. William Kaufman, B-3, and arthritis. J Orthomolecular Med, 2001. Vol. 16, No. 3, Third Quarter, 2001, p 189. The world was still deep in the Great Depression when William Kaufman, MD, PhD, had already begun treating osteoarthritis with two to four grams of niacinamide daily. Now, over 60 years later, his pioneering work in orthomolecular medicine is receiving the recognition it so well deserves.
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